Hepatic uptake of -butyrobetaine, a precursor of carnitine biosynthesis, in rats
نویسندگان
چکیده
Masaharu Fujita, Takeo Nakanishi, Yuta Shibue, Daisuke Kobayashi, Richard H. Moseley, Yoshiyuki Shirasaka, and Ikumi Tamai Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa; Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Hokkaido, Japan; and Department of Internal Medicine, Ann Arbor Veterans Affairs Healthcare System and University of Michigan School of Medicine, Ann Arbor, Michigan
منابع مشابه
The role of the kidney in the biosynthesis of carnitine in the rat.
Intravenous administration of L-[methyl-3H]-labeled trimethyllysine to rats results in a very rapid accumulation of radioactivity by the kidneys, while the incorporation of the label into the liver occurs at approximately 1% of this rate when calculated per g of wet tissue. The kidneys convert a substantial portion of the trimethyllysine taken up to butyrobetaine and to beta-hydroxytrimethyllys...
متن کاملRole of Lysine and s-NTrimethyllysine in Carnitine Biosynthesis
We have previously reported that weanling rats fed a 20% wheat gluten diet, limiting in lysine and containing no detectable carnitine, have significantly lower levels of carnitine in skeletal and heart muscle than rats receiving adequate dietary lysine. Rats on 20% wheat gluten diets were administered appropriate levels of DL-[6-i*C]lysine, L-[mefhyZ3H]methionine, t-N-[mefhyZ-3H]trimethyl-L-lys...
متن کاملBiosynthesis of carnitine and 4-N-trimethylaminobutyrate from 6-N-trimethyl-lysine.
The conversion of 6-N-[Me-(14)C]trimethyl-lysine into carnitine and 4-N-trimethylaminobutyrate (butyrobetaine) was demonstrated in rats kept on a lysine-deficient diet. After the rats were given [(14)C]trimethyl-lysine for 4 days, a total of 17% of the injected label was recovered as carnitine from carcass and urine extracts. Another 8% of the trimethyl-lysine label was converted into 4-N-trime...
متن کاملExpression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation
BACKGROUND In rodents and pigs, it has shown that carnitine synthesis and uptake of carnitine into cells are regulated by peroxisome proliferator-activated receptor α (PPARA), a transcription factor which is physiologically activated during fasting or energy deprivation. Dairy cows are typically in a negative energy balance during early lactation. We investigated the hypothesis that genes of ca...
متن کاملEffect of Aerobic Training and L-Carnitine Supplementation on Hepatic Oxidative Stress Factors in Diabetic Rat
Objective: The use of non-enzymatic antioxidants in food supplements and proper exercise can have a positive effect on decreasing oxidative stress by free radical hunting. The purpose of this study was to investigate the effect of aerobic training and L-carnitine supplementation on some of the oxidative stress factors in the liver of diabetic rats. Materials and Methods: In this experimental s...
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